Thioredoxin has also been shown to bind to ASK1 to inhibit its action like a kinase [32]. This inhibition is attenuated by ROS that can cause dimerization of thioredoxin [33]. Thioredoxin regulation in the glucocorticoid receptor as a result of Affiliation with the DNA binding domain has also been described [34] and this also is motivated by ROS. A

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